Abstract
E-mail: sycho@cau.ac.krReceived October 9, 2013, Accepted October 21, 2013Key Words : DUSP13A, PTP inhibitor V, PTP inhibitorProtein phosphorylation is regulated by two groups ofenzymes, protein kinases and protein phosphatases. Regula-tion of phosphorylation has been a target for development oftherapeutic reagents for many human diseases. Most proteinphosphatases are members of protein tyrosine phosphatases(PTPs). The human genome encodes 107 PTPs, which areclassified into four families: (i) class I cysteine-based PTPs,contains 2 classical PTPs and VH1-like PTPs, (ii) class IIcysteine-based PTPs; tyrosine-specific low molecular weightphosphatases (LMPTP), (iii) class III cysteine-based PTPscontaining cell division cycle25 (CDC25) homology (CH2)domain, (iv) transcription factors Eyes absent (EYA) proteinsas members of aspartic acid based PTPs.
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