Abstract

The protein phosphorylation level is regulated by the balance between activities of protein kinases and phosphatases. The protein tyrosine phosphatase (PTP) superfamily comprises almost 100 enzymes. Based on the amino acid sequences of their catalytic domains, the PTPs can be grouped into four main families: (i) classical PTPs and dual-specificity protein tyrosine phosphatases (DUSPs), (ii) tyrosine-specific low molecular weight phosphatases, (iii) the cdc25 family, and (iv) Eyes absent (EyA) protein that was re-cently discovered to be tyrosine-, or dual serine- and ty-rosine-specific protein phosphatases.

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