Abstract
Hepatitis B virus (HBV) infection is a worldwide public health problem, which can lead to life threatening chronic hepatitis, liver cirrhosis and cancer. Despite this, treatments for chronic HBV infection are still very limited. In our investigation of herbal medicines as antiviral agents, FF, the lipid soluble fraction of Ferula ferulaeoides, which has been used as a traditional Chinese medicine, showed a significant inhibitory effect against HBV in HBV-producing cell line HepG2.2.15. In the experiment, FF reduced the HBsAg level and HBV replication by 87 and 36%, respectively. The results suggest that the lipophilic fraction of root extracts from F. ferulaeoides could serve as an effective natural constituent of herbs for the search of novel anti-HBV agents. Key words: Hepatitis B Virus, anti-HBV, HBsAg, Ferula ferulaeoides.
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