Abstract
Prostacyclin (PGI 2) synthesis by human mesenteric arteries and veins was measured ex vivo in 62 patients who received either no medication or a single oral dose of aspirin 40 mg, 75 mg or 300 mg approximately 24 hrs pre-operatively. Each dose of aspirin caused a significant reduction in both arterial and venous PGI 2 synthesis compared with the untreated group. Arterial PGI 2 synthesis did not differ significantly from venous PGI 2 synthesis whether assessed by sample weight or sample area.
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