Abstract
Pyriformis muscles of the frog were denervated by section of the sciatic nerve. About three weeks later all slow muscle fibres examined had become capable of generating action potentials. However, the action potential mechanism failed to develop if actinomycin D was injected early after the operation. It is suggested that RNA synthesis is required for the formation of ‘Na channels’ in the membrane of denervated slow muscle fibres.
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Schedule a callMore From: Proceedings of the Royal Society of London. Series B, Biological sciences
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