Abstract
Inherited real risk of Alzheimer's disease: bedside diagnosis and primary prevention.
Highlights
Mitochondria dysfunction (Leuner et al, 2012) and blood-brain barrier (BBB) impairment (Deane and Zlokovic, 2007) are novel researches and insights into the pathogenesis of Alzheimer’s Disease (AD), which could lead to classification of AD as a neurovascular disease
In the frame of Quantum Biophysical Semeiotics (QBS) theory, the combination of Clinical Microangiology and “Angiobiopathy” theory (Stagnaro, 2009a), allows to merge the hypothesis of AD as neurological microvascular—based disease and the researches focused on mitochondrial dysfunction according to the inherited genetic causes of this neurodegenerative pathology, i.e., the congenital alteration of mit-DNA in related neuronal cells
In case of intense pressure on brain’s trigger points related to AD if the reflex appear simultaneously there is an Inherited Real Risk (IRR) of brain disorder linked to AD, but only if the intensity of the reflex is more than 1 cm: positive specific QBS sign due to the fact that the remodeling is present in the typical areas of AD
Summary
Mitochondria dysfunction (Leuner et al, 2012) and blood-brain barrier (BBB) impairment (Deane and Zlokovic, 2007) are novel researches and insights into the pathogenesis of Alzheimer’s Disease (AD), which could lead to classification of AD as a neurovascular disease. QBS theory offers an approach “as a whole” of the patho-physiology of inherited mitochondrial neurodegenerative diseases, as well as that of AD in its various forms, characterized by an Inherited Real Risk (IRR) of Brain Disorders (Stagnaro and Caramel, 2011).
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