Inhalation fluticasone propionate in treatment of children with cough variant asthma

Abstract

Objective To observe and compare the clinical efficacy, recurrence rate and safety of different courses of inhalation fluticasone propionate in treatment of children with cough variant asthma. Methods A total of 101 children with cough variant asthma in our hospital were randomly divided into three treatment groups, all with the same therapy drug -fluticasone propionate and with the treatment time of two months, six months and nine months respectively.Clinical efficacy and treatment compliance were followed up during the treatment.After discontinuation, observation for the relapse of cough was followed up for 6 months.In inhalation therapy before and after, bone mineral density(BMD)and blood cortisol, electrocardiogram were monitored respectively to observe its safety. Results Three groups of children with cough were all get effective control, with no significant difference(H=5.2894, P=0.0710). The two months treatment group(A group)was more easy to relapse than the six months treatment group(B group)and the nine months treatment group(C group)after drug withdrawal, statistically significant(χ2=4.858 1, P=0.027 5; χ2=4.482 6, P=0.034 2). But after drug withdrawal, there was no significant difference in the rate of relapse in B and C group(χ2=0.022 2, P=0.881 4). There were few changes in laboratory values about morning serum cortosol concentrations.There was no significant decrease in BMD after treatment.No other adverse events were observed in this study. Conclusion Fluticasone propionate inhalation treating children cough variant asthma has good effection.A long period of treatment scheme(6 months)has better curative effect and lower recurrence rate after drug withdrawal. Key words: Children; Cough variant asthma; Curative effect; Recurrence rate; Safety