Inhalation anesthesia induced by isoflurane alters penicillin disposition in swine tissues.

Abstract

Twelve healthy swine were dosed with penicillin G intramuscularly. Fluids and tissues samples were collected at the end of two periods of general anesthesia, performed 24h apart. Tissue samples were collected by minimally invasive laparoscopy under general anesthesia at 8 and 28h postdose. Four nonanesthetized, penicillin-treated pigs were euthanized at 8h postdose, and a second set of four similarly treated control pigs were sacrificed 28h postdose. Liver penicillin tissue concentrations from animals that underwent anesthesia and laparoscopic tissue collection had tissue concentrations that were higher than nonanesthetized pigs at both time points. Urine, plasma, kidney, skeletal, and cardiac muscle showed no differences between the two groups. Laparoscopic tissue collection under general anesthesia in swine induces physiological changes that cause alterations in tissue pharmacokinetics not seen in conscious animals.