Effect of preoperative sleep disturbance on the consumption of propofol during general anesthesia and postoperative sleep quality

Abstract

Objective To evaluate the effects of preoperative sleep disturbance on the consumption of propofol during the period of general anesthesia and postoperative sleep quality. Methods Sixty-five patients scheduled for elective thyroidectomy surgery under general anesthesia were enrolled in the study. According to the preoperative Pittsburgh Sleep Quality Index (PSQI) score, the patients were divided into sleep normal group (n=33) and sleep disorder group (n=32). Anesthesia was induced and maintained with propofol given by closed-loop target-controlled infusion (CLTCI). The consumption of propofol during the period of general anesthesia, postoperative sleep quality in the evening of surgery and at 24 h after operation, and the painful levels of the patients at 1 d and 2 d after operation were compared between two groups. Results The total consumption of propofol in sleep disorder group [(1 024.33±213.02)mg] was more than that in sleep normal group [(892.25±242.30)mg] (P<0.05), and the dosage of unit surface area per minute of propofol in sleep disorder group [(4.94±0.80)mg/(min·m2)] was also more than that in sleep normal group [(4.45±0.96)mg/(min· m2)] (P<0.05). Each group suffered from bad sleep quality in the evening of operation, and got improvement one day later (P<0.05). The sleep quality in sleep disorder group was improved after general anesthesia (P<0.05). Conclusions Preoperative sleep disturbance increased the consumption of propofol in the general anesthesia. General anesthesia can improve the sleep quality of the patients who suffered from sleep disorder. Key words: Sleep disorders; Anesthesia, general; Propofol/AD; Sleep