Abstract
Development of abdominal aortic aneurysms (AAAs) evolves through stages from normal aortic size to mild ectasia and further dilation to small aneurysm. This study analyzed the proximal aortic neck, which may be susceptible to pharmacologic modification by metalloproteinase inhibition (with doxycycline) at a smaller aortic size. In addition, endovascular aneurysm repair is dependent on stability of this aortic neck for sealing and fixation, which could be compromised by aortic dilation. This study compared neck diameter during 2 years in patients from the Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA3CT; NCT01756833) based on the randomized study arm.
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