Abstract
Plasma is becoming increasingly adopted in bioapplications such as plasma medicine and agriculture. This study investigates the interaction between plasma and molecules in living tissues, focusing on plasma-protein interactions. To this end, the reaction of air-pressure air plasma with NH2-terminated self-assembled monolayer is investigated by infrared spectroscopy in multiple internal reflection geometry. The atmospheric-pressure plasma decomposed the NH2components, the characteristic units of proteins. The decomposition is attributed to water clusters generated in the plasma, indicating that protein decomposition by plasma requires humid air.
Highlights
Plasma technology has been adopted in Si-based semiconductor technologies [1,2,3,4,5]
As test molecules for evaluating how plasma reacts with biological tissues, we focus on self-assembled monolayers (SAMs) [21,22,23,24], assemblages of monomers deposited on substrate
We suggest that water clusters are generated by the atmospheric-pressure air plasma and become absorbed on the OTS-SAM, we need crosschecking with other methods such as mass spectroscopy
Summary
Plasma technology has been adopted in Si-based semiconductor technologies [1,2,3,4,5]. Plasma bioapplications have been extensively investigated [10,11,12,13,14,15,16], the plasma effect is optimized by multiple repeat experiments, the so-called “trialand-error” approach. Biomolecules with small molecular weights are preferable [20], but it is difficult to analyze their reactions to plasma, because their molecules still have complicated structures with various function groups such as N–H, C–H, and C=O bonds. Appropriate monomers can form SAMs on a Si surface by siloxane (Si–O) bonds [21] This advantage is beneficial for us, because we have developed “infrared absorption spectroscopy in multiple internal reflection geometry” (MIR-IRAS) using MIR prism made from a Si wafer [30,31,32,33,34].
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