Influenza vaccines and immunopathology

Abstract

“…the concern over immunopathology resulting from T-cell responses to nucleoprotein or other conserved antigens in the absence of neutralizing antibodies in humans can be narrowed to high-dose infections with some pandemic viruses, although both in 1918 and 2009, there is evidence that T-cell responses were more likely to be responsible for protection than increasing disease severity.” Expert Review Vaccines