Abstract
To the Editor:— Dr. Tuft is correct in nearly all that he has stated in his reply to my recent answer published in your QUESTIONS AND ANSWERS column. However, I do not think he really takes issue with me, because we seem to be in agreement except for the matter of emphasis. In his discussion of the efficacy of intradermal vaccination he underlines what I had already stated. The only major disagreement would be his comments upon the incidence and severity of reactions after subcutaneous administration of influenza vaccines. The paper which he cites is from a 1962 report and the data would not be tenable with present vaccines. The improvements in technology of vaccine development and production have resulted in influenza antigens which are far less reactigenic, and the presently available vaccines prepared by zonal ultracentrifugation are practically free of reactions in many populations. Nevertheless, I must continue to
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