Abstract
Measles dominates among child droplet infections in many countries. This disease is still an important health problem and is still the major killer in children. Immunization of all humans sensitive to this infection is the only radical measure in the struggle against measles. The quality of a vaccine is primarily determined by the properties of the virus strains, technology of production and the cell substrate. Live measles vaccine is produced at present in 15 countries of the world. Hen eggs from SPF farm and MRC-5 diploid cells of human embryo lung are used as a substrate. Production of live measles vaccine in primary cell cultures has a number of drawbacks caused by nonstandard character of the substrate and probability of contamination. The use of certified human diploid cells deposited in liquid nitrogen in sufficient quantities shows promise most of all. We have developed a new technology of live measles vaccine production by using the Leningrad -16 virus strain (L-16) on the basis of the L-68 diploid cell culture of human embryo lung.
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