Influence the diphenhydramine hydrochloride–sodium carboxymethyl cellulose complex for nanoaggregate formation

Abstract

This study aimed to create nanoaggregates that improve the synergistic interaction between the opposing charges in drug-polyelectrolyte complexes. In this study, sodium carboxymethyl cellulose (NaCMC) polyelectrolytes and diphenhydramine hydrochloride (DPC) drug molecules were used to form the nanoaggregate. The aggregation behaviour of NaCMC-DPC complexes was determined by using conductivity methods. The critical micelle concentrations (CMC) of NaCMC were reduced from 0.737 to 0.337 g/l in the aqueous and 29.18 mg/l in the DPC. The modified Corrin and Harkins (CH) and Frahm's approaches evaluated the binding efficiency of the NaCMC-DPC interaction. NaCMC-DPC complexes were examined by transmission electron microscopy (TEM) and dynamic light scattering (DLS) techniques to conform to the formation of bilayer vesicles. Furthermore, we prepared the silver nanoparticles by using NaCMC-DPC complex mixtures. We demonstrated how NaCMC-DPC mixtures might influence the self-assembly of silver nanochain designs that differed from open "end-to-end" networks. The results indicated that the assembly of silver nanochains was regulated by a variation of electrostatic interactions inside the NaCMC-DPC components, which organized themselves around anisotropic nanochains surfaces. Among the optical properties altered by the linear assembly, the longitudinal surface plasmon resonance band at 624 nm has an enhanced redshift.