Abstract
Background: Singlet oxygen (1O2) oxidizes targets through the production of secondary reactive oxygen species (SOS). Cancers induce oxidative stress changing with progression, the resulting antioxidant status differing from one patient to the other. The aim of this study was to determine the oxidative status of patients with resectable Non-Small cell lung cancers (NSCLC) and the potential influence of antioxidants, compared to sera from healthy donors. Materials and Methods: Serum samples from 10 women and 28 men, 19 adenocarcinomas (ADK), 15 patients N1 or M1 were submitted to a photoreaction producing 1O2. Then, samples were supplemented with vitamins (Vit C, Vit E), or glutathione (GSH). Results: Squamous cell carcinomas (SCC) and metastatic SCCs induced a lower SOS rate. While Vit C increased SOS in controls as in patients with metastases, Vit E or the combination of Vit E and C strongly reduced SOS. GSH alone lightly decreased SOS in controls but had no effect in patients either alone or combined with Vit C. Conclusion: In “early” lung cancers, SOS are comparable or lower than for healthy persons. The role of Vitamins varies with gender, cancer type, and metastases. This suggests that an eventual supplementation should be performed on a per-patient basis to evidence any effect.
Highlights
A number of diseases are oxidative stress-related, including cancers that are prone to inducing oxidative stress at any step of their development from induction to metastasis [1,2], this oxidative stress even being increased in the particular case of cancer-induced pulmonary obstruction [3].In addition, most anticancer treatment procedures act through oxidative processes and are associated with significant mortality and morbidity or an inflammatory response
We demonstrated that resistance to secondary reactive oxygen species (SOS) was decreased in advanced cancers—experimentally and in patients [9,10]—and recently, a correlation between antioxidant, Vitamins (Vit) and inflammation biomarkers had been observed in patients with metabolic syndrome [11], something that could to some extent influence cancer growth
There was no statistical difference between male or female controls, there was a trend towards a lower SOS production in male sera (p < 0.08)
Summary
A number of diseases are oxidative stress-related, including cancers that are prone to inducing oxidative stress at any step of their development from induction to metastasis [1,2], this oxidative stress even being increased in the particular case of cancer-induced pulmonary obstruction [3].In addition, most anticancer treatment procedures act through oxidative processes and are associated with significant mortality and morbidity or an inflammatory response. Among the factors that influence this inflammatory response, oxidative stress has been shown to play a major role, being related to either the disease or the patient This oxidative stress results in the formation of reactive oxygen species (ROS) and peroxides originating from various cellular and enzymatic sources and leads to the depletion of plasma physiological antioxidants, increasing peroxidation and causing additional tissue damage [4]. We studied the influence of substances classically prescribed for their anti-oxidative properties on SOS production and de-activation in sera from 28 men and 10 women with Non-Small Cell Lung Cancers (NSCLC), consecutively recruited. These cancers were all considered as being resectable, one node or metastasis had been detected in 15 patients.
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