Influence of Triiodothyronine and Dexamethasone on the Postnatal Development of Hepatic Eosine Transport in Rats

Abstract

In male Wistar rats of different ages the influence of a three days pretreatment with triiodothyronine (T3, 100 micrograms/kg b.m.s.c.) or dexamethasone (0.4 mg/kg b.m.i.p.) on eosine accumulation of rat liver in vitro and biliary excretion of eosine in vivo was investigated. T3 stimulated the eosine accumulation in liver slices. This in vitro effect was not paralleled by higher serum elimination rates of eosine in vivo. Neither T3 nor dexamethasone could accelerate the maturation of the rate limiting excretion process for organic anions in developing rats.