Abstract
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Va c e k A. : Proliferation Activity and Number of Stromal and Haemopoietic Stem Cells in Bone Marrow and Spleen of Rats of Different Ages
For the determination of numbers of colony-forming units (CFUs)-f an in vitro liquid culture was used. Proliferation activities of both types of cells were evaluated in vivo after intraperitoneal administration of hydroxyurea. The numbers of both CFU-f and CFUs increased in the femoral bone marrow cavity while they decreased in the spleen within the period from one to five months of the rat age
The total number of nucleated cells per marrow cavity of the femur was higher in the aged rats than in the young ones, in the spleen only slight differences were observed with advancing age of rats
Summary
Va c e k A. : Proliferation Activity and Number of Stromal and Haemopoietic Stem Cells in Bone Marrow and Spleen of Rats of Different Ages. Proliferation activities of both types of cells were evaluated in vivo after intraperitoneal administration of hydroxyurea The numbers of both CFU-f and CFUs increased in the femoral bone marrow cavity while they decreased in the spleen within the period from one to five months of the rat age. The purpose of this study was to characterize the proliferation activity and the size of the compartment of the stromal stem cells (CFU-f) in the bone marrow and spleen of rats of different ages and to evaluate the relationship between the CFU-f and CFUs in the haemopoietic activity of both tissues. The results show evidence of intrinsic changes in the proliferative activity of CFU-f compartment in the course of 7 month of age and indicate on the relation of changes in the compartment of CFU-f to the haemopoietic activity in normal life and after irradiation
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