Abstract
The structure-activity relationships for the interactions of a number of sulfhydryl compounds on the transformation of (Z)-3-(4-bromophenyl)-3-(3-pyridyl)allylamine (CPP 200) by an MPO-H 2O 2-Cl −-system at pH 5.25 have been studied. It was found that the inhibitory effect of the thiol group was strongly dependent on the presence of an electron-withdrawing NH 3 +-group in the molecule. Also, the acid-base properties of the thiolic compounds were involved in the inhibitory mechanisms.
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