Influence of the “Active Mix” supplement with separate administration of antagonistic components on the structure of the mice internal organs

Abstract

The question of the need for separate administration of feed additives’ components that are antagonistic from the point of view of their chemical properties and physiological effects has long been debated among researchers. The authors have proposed a new supplement based on chelate compounds, which components’ effect on the organism of laboratory animals has been partially considered earlier. However, the assessment of the components’ effects on the morphology of the excretory and reproductive systems’ organs has not been studied. In this regard, the work considered the effect of feed additive components with separate introduction of chemically and physiologically antagonistic components on the pathoanatomical picture, as well as the microstructure of the kidneys and testes of laboratory mice to assess potentially negative effects on the excretory and reproductive systems. The supplement was administered orally at various dosages. The organ structure was assessed after 1, 2 weeks and 1 month. The microstructure of the kidneys and testes was histologically studied in the experiment and control. The negative influence absence of the supplement components in the entire range of applied dosages is shown. The absence of visible deviations of the pathoanatomical picture during autopsy of experimental animals was noted.