INFLUENCE OF SYSTEMATIC TAKING BLOCKERS OF H2-HISTAMINE RECEPTORS ON THE DEGREE OF SEMINATION OF GASTRIC MUCOSA WITH HELICOBACTER PYLORI INFECTION OF PATIENT WITH CHRONIC NON – ATROPHIC GASTRITIS

Abstract

The aim: To determine the effect of prolonged use of H2-histamine receptor blockers on the degree of contamination of the gastric mucosa with HP infection in patients with chronic non-atrophic gastritis. Materials and methods: 28 patients with chronic atrophic gastritis (the main group), who regularly took H2-histamine receptor blockers for 2 to 7 years, and 30 patients (control group), who never used them were comprehensively examined. Comprehensive examination included: step-by-step intragastric pH-metry, esophagogastroduodenoscopy, helicobacter infection test (НР) (helicobacter urease test and microscopic examination of stained smears), histological investigations of the gastric stump mucous, material for which was taken during endoscopy from 4 topographical zones: from the middle third of the gastric antrum and body of stomach on the big and small curvature. Results: All the patients in 100% of cases have confirmed the existence of chronic non-atrophic gastritis in both active and inactive stages of varying degrees of severity. Helicobacter infection was detected in 100% of cases. A comparative analysis of the data on the average degree of infection of the gastric mucosa by HP infection in the same topographic zones in the patients of the main and control groups revealed a significant (p <0.05) higher degree of seeding of the gastric mucosa in patients of the main group in all zones. Conclusions: Monotherapy for chronic non-atrophic gastritis with blockers of Н2-histamine receptors leads to an increase in the degree of gastric mucosa semination with HP infection. This fact requires mandatory parallel use of antibacterial agents - colloidal bismuth subcitrate and antibiotics, with blockers of Н2-histamine receptors.