Abstract
At the 14th to 16th week of pregnancy the copper content in the maternal liver was low while that in the fetus was high. After ovariectomy there was a decrease in liver copper and ceruloplasmin which was prevented by treatment with oestrogens but not with progesterone. Five groups of sheep were studied: control (barren ewes), pregnant, ovariectomised and ovariectomised treated with oestrogens or progesterone. In all, with high or low liver copper, the nuclear fraction contained the most copper. This suggests a species specificity of the copper metabolism in sheep.
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