INFLUENCE OF RBC COUNT AND HAEMOGLOBIN CONCENTRATION ON PLATELET RICH FIBRIN NETWORK AMOMG DIFFERENT AGE GROUPS AND GENDER- A CROSS SECTIONAL STUDY.

Abstract

AIM: To determine the influence of RBC count and hemoglobin concentration on the density of PRF network among individuals of different age groups and gender. MATERIALS AND METHODS: 82 individuals were divided into three groups based on their age, Group 1: 20-30 years, Group 2: 30-45 years, & Group 3: 45-60 years. 3-4 ml of venous blood samples were collected, PRF were prepared and it was subjected to histological analysis to determine the age and gender related changes in the density of PRF network. Hematological parameters such as Hb concentration and RBC count were also evaluated and correlated with the density of PRF network. RESULTS: Group 1 showed predominantly dense fibrin network, Group 2 showed mixed pattern including both dense and loose fibrin network and Group 3 showed predominantly loose fibrin network. However the difference in fibrin network among different age groups was not statistically significant (p value-0.14). Among the gender, males showed dense fibrin network compared to females which was statistically significant with p value-0.03. There was no statistically significant correlation between RBC count and density of fibrin network with p value-0.11. There was a statistically significant correlation between Hb level and density of fibrin network with p value-0.05. CONCLUSION: The PRF which is widely used in periodontal regenerative therapy differ in densities between male (dense network) and female (loose network). It is found to be denser in individuals with high hemoglobin concentration.