Abstract
Summary: In order to assess the role of proteinuria in the development of lipoprotein metabolism derangements, we investigated 60 patients (32 males and 28 females, mean age 37.15 ± 9.85 years, average clearance of endogenous creatinine 86.27 ± 19.81 mL/min, average body mass index 24.18 ± 2.23 kg/m2), distributed in four groups according to degree of glomerular proteinuria. The control group, with urinary protein excretion 3.0 g/24h had significantly higher serum HDL cholesterol (p 3.0 g/24h as compared with patients with proteinuria ranging from 1.0 to 3.0 g/24h and control subjects (p<0.01). We therefore conclude that proteinuria causes disorders of LDL, VLDL, HDL and lipoprotein (a) metabolism.
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