INFLUENCE OF PROSTAGLANDIN SYNTHESIS INHIBITOR ON CEREBRAL PERFUSION AND OXYGEN METABOLISM DURING NOR-MOTHERMIC CARDIOPULMONARY BYPASS

Abstract

Cerebral blood flow during cardiopulmonary bypass ICPB) is basically autoregulated, hut deranged to some extent when systemic pressure is severely reduced such as normothermic CPB INCPB). We reported that the hypotension during NCPB could be restored to normotension with PC synthesis inhibitor (PGSI). However, it was not clear how PGS1 influenced cerebral perfusion. We examined cerebral blood flow and oxygen metabolism during NCPB in the case d PGS1 infusion. NCPB was experimented in 8 adult goats. To control the perfusion pressure in 50–80 mmHg, PGS1 was administered in Group-P (n = 4), while notepinephrine was in Group-C (n = 4) as a control. The total systemic flow was ajusted around 70 ml/kg/min. Tissue blood flow was measured with the colored microsphere method before and at 30 and 60 minutes of CPB. Blood flows in the carotid artery were comparable between the groups, but those in the cerebral tissue in Group-P were significantly increased more than those in Group-C (P < 0.05). Jugular and mixed venous oxygen saturation and extraction rate were comparable between the groups, whereas the jugular venous blood lactate level in Group-P were slightly lower than those in Group-C (at 60 minutes: 36.0 + −6.6 vs 44.0 + −7.2 mg/dl, P=0.08). In conclusion, PGS1 restores perfusion pressure during NCPB without impairing cerebral perfusion.