Abstract
Purpose: To investigate the effect of starvation on contrast-enhanced CT of the liver using the iodinated hepatocyte-specific lipid emulsion FP 736–04. Material and Methods: CT examination of the liver was performed in Sprague-Dawley rats before and after an i.v. infusion of 1.0 ml/kg b.w. of FP 736–04. The examination was preceded by a 15-h period of food withdrawal (the starvation group). A control group was subjected to the same CT examination protocol with use of FP 736–04 but without prior starvation. Results: Liver attenuation values did not differ significantly between the starvation and the control group (p>0.05). Conclusion: A pre-examination period of starvation had no effect on FP 736–04 liver enhancement on CT. However, liver attenuation tended to decrease more slowly in the starvation group than in the controls.
Published Version
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