Influence of polylactic acid and polycaprolactone on dissolution characteristics of ansamycin-loaded polymeric nanoparticles: An unsatisfied attempt for drug release profile

Abstract

Objectives: The purpose of the current examination was to establish a polymeric nanoparticle (NP) to supply Ansamycin to the central nervous system by improving blood–brain barrier permeability for bacterial meningitis, by emulsification solvent diffusion technique with numerous hydrophilic carriers. Materials and Methods: The polymeric NPs were prepared by emulsification solvent diffusion technique making use of Polylactic acid (PLA) as well as Polycaprolactone (PCL). Physical mixtures of drug with above-mentioned polymers were likewise prepared. The formulations were examined for Fourier-transform infrared spectroscopy and as well as differential scanning calorimetry (DSC), particle size, and also in vitro dissolution. Similarity factor (f2) was determined for the comparison between dissolution of pure drug and also drug polymer physical mixtures with NPs. Results: Phase solubility researches showed linear increase in the drug solubility with rise in carrier concentration. In vitro release studies disclosed that dissolution quality of Ansamycin was not satisfactory with PLA and also PCL for the release quality of the Ansamycin from the formulation. Nanoformulation of Ansamycin with PLA and also PCL displayed inadequaterate and extent of dissolution. Optimized batches of nano formulations of both the carriers were identified by the Fourier-transform infrared spectroscopy and also DSC evaluation, which suggested existence of interactions between ansamycin and carriers. Conclusions: PLA as well as PCL are not the appropriate polymers to serve as a carrier to deliver Ansamcyin.