Influence of PNS on the levels of TGF-β1, TIMP-1 for renal fibrosis in patients with chronic renal failure

Abstract

Objective To evaluate the clinical prevention and cure efficiency of panax notoginosides (PNS)in patients with chronic renal failure. Methods 60 patients with chronic renal failure were selected and randomly divided into the control group and the observation group, with 30 cases in each group by random number table. The patients in the control group underwent regular maintenance hemodialysis(MHD), while the patients in the observation group were given PNS glucose injection on the base of the control group for two months treatment.Comparison was made between the two groups in the aspect of liver filament four items,renal function, blood lipids and the levels of TGF-β1,TIMP-1 expression for renal fibrosis. Results After two months treatment, the liver filament four items(t=3.94-5.62, all P<0.05), renal function(t=4.15,4.29,all P<0.05),blood lipids(t=3.83-5.47, all P<0.05)and the level of TGF-β1,TIMP-1 were all significantly decreased in the observation group,while HA,blood lipids and the level of TGF-β1(t=5.19,P<0.01),TIMP -1(t=4.16,P<0.05)were also decreased in the control group.All the indexes of the observation group were much significant than those of the control group.Total effective rate of the observation group was 83.33%, which was significantly higher than 66.67%of the control group(χ2=5.16,P<0.05). There was no adverse reaction in the observation group. Conclusion PNS could improve renal fibrosis by lowering the level of TGF-β1and TIMP-1, and could be used as conventional auxiliary drug for patients with chronic renal failure. Key words: Kidney failure, Chronic; Fibrosis; Transforming growth factor beta1; Matrix metalloproteinase 1