Abstract
The aim of the present study was to investigate the effect of platelet rich fibrin (PRF), a second generation platelet concentrate, on biomechanical properties of primary sutured cutaneous incisional wounds. Acute incisional wounds were made on the right and left side of the vertebral column of 15 adult mixed breed dogs. PRF membrane prepared from the venous blood of each animal was placed between the edges of the left side incisions while the right side incisions were used as controls. All incisions were sutured and skin samples were taken on days 3, 7 and 14 post-wounding for biomechanical analysis of wound strength. Mean breaking and tensile strength of PRF treated wounds were 48% and 52% greater than the control wounds at day 7 respectively which was statistically significant. Mean breaking stress of PRF treated wounds was also significantly greater than the controls at day 3 (16.42[Formula: see text][Formula: see text][Formula: see text]7.73 versus 9.823[Formula: see text][Formula: see text][Formula: see text]6.018). No significant difference in Young’s modulus of elasticity was observed between the treatment and control wounds. The results demonstrate that PRF improves the biomechanical properties of the healing incisional wounds especially in the first week. This could have positive implications particularly in patients suffering from conditions which adversely affect wound healing such as diabetes both in animals and humans although further studies are required.
Published Version
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