Abstract
Plasma concentration-time profiles for amidopyrine and its primary desmethyl metabolite have been determined in control rats and in rats pretreated with phenobarbitone. The kinetics of both compounds indicate enhanced clearance following pretreatment. Metabolite excretion in urine, bile and breath support the plasma data. It would appear that pheno barbitone pretreatment results in quantitative but not qualitative changes in the metabolism of amidopyrine in rat.
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