Abstract
The aim of the study was to evaluate the effectiveness of P. scabiosifolia in correcting the physiological and psychosomatic state of mice exposed to acute and prolonged whole-body vibration. The effect of a 40% water-alcohol tincture from the roots of P. scabiosifolia was investigated in CD-1 mice under the influence of whole-body vibration induced by a shaker or exposure to road transportation. Emotional, exploratory-oriented and motor behavioral components were observed in the open field. Physical performance was evaluated by the duration of swimming until fatigue with a 7% weight attached to the tail root. Metabolic indices were serum corticosterone, glycogen, lactate and adenosine triphosphate of the liver and skeletal muscle. The orally administered drug at a dose of 5 ml/kg optimized the behavioral reactions of the animals, increased their exercise performance, improved hormonal status, and energy metabolism in liver and skeletal muscle and tissues under the influence of whole-body vibration. The P. scabiosifolia tincture possesses a vibroprotectiveeffect and can be recommended for the prevention and treatment of neurophysiological disorders caused by whole-body vibration, in combination with basic therapy.
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