Abstract
Influence of synthetic analogue of arginine-vasopressin (AVP), Ac-D-SPRG, on exploratory behavior and level of anxiety of white rats was investigated. Ac-D-SPRG was injected nasally in doses of 0.01, 0.1, 1.0, and 10.0 μg/kg in the volume of 1 μl per 10 g of body weight 5 min before the testing. The analogue caused depression of orientation and exploratory activity (OEA) and increase of anxiety level in animals. The contradictory literature data provide no opportunity to conclude unambiguously on mechanisms underlying bases of regulation of anxiety level and OEA from AVP but nevertheless confirm the participation of this hormone in a given process.
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