Abstract
Survival curves were obtained for haploid and diploid yeasts, Saccharomyces cerevisiae, of a wild-type strain and radiosensitive mutants exposed to gamma-rays in oxygenated and hypoxic conditions both in the absence and in the presence of misonidazole. Misonidazole enhanced the radiosensitivity only of hypoxic cells. A correlation between oxygen and misonidazole sensitization was observed. The data confirm that misonidazole mimics the sensitizing effect of oxygen. The degree of liquid-holding recovery of yeast cells was greater when the cells were irradiated in hypoxic conditions with than without misonidazole. Possible reasons for the observed radiation responses are discussed.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call