Abstract
To evaluate the effects of metoclopramide on abdominal wall healing in rats in the presence of sepsis. 40 rats divided into two groups of twenty animals, subdivided into two subgroups of 10 animals each: group (E) - treated with metoclopramide, and saline-treated control group. The two groups were divided into subgroups of 10 to be killed on the 3rd day (n = 10) or day 7 (n = 10) after surgery. Sepsis was induced by cecal ligation and puncture. We performed also the section and anastomosis in left colon. The synthesis of the abdominal wall was made with 3-0 silk thread. We measured the breaking strength of the abdominal wall and made the histopathological evaluation. on 3rd day postoperative, the average breaking strength in the E group was 0.83 ± 0.66 and in group C was 0.35 ± 0.46 (p = 0.010). On the seventh day, the breaking strength in group E was 11.44 ± 5.07, in group C 11.66 ± 7.38 (p = 1.000). The E7 group showed lower inflammatory infiltration, foreign body reaction, fibrin than control. animals treated with metoclopramide had a higher resistance of the abdominal wall on the 3rd postoperative day.
Highlights
Nausea and vomiting are the most common complications after surgery, antiemetics are frequently prescribed[1]
Metoclopramide is the most widely used antiemetic in hospital-clinical setting, but their use is very questioned due to potential side effects - drowsiness, extrapyramidal seizures and agitation2,3..There are few studies relating the use of this drug with its peripheral actions in wound healing, especially in the presence of sepsis
P = 0,558 p = 0,387 FIGURE 1- Weight of animals euthanized on the 3rd postoperative day p = 0,460 p = 0,774 FIGURE 2 - Weight of animals euthanized on the 7th postoperative day 94 - Acta Cirúrgica Brasileira - Vol 26 (Suppl. 2) 2011
Summary
Nausea and vomiting are the most common complications after surgery, antiemetics are frequently prescribed[1] Among these kinds of drugs, the use of peripheral and central antidopamine is of great interest. These drugs act on dopamine receptors in the trigger zone avoiding the vomit. The widespread infection stems from a severe sepsis in which there is an intense oxidative stress by the releasing of reactive oxygen species and proinflammatory cytokines[4,5]. It interferes in the process of healing[5] and is a risk factor for dehiscence
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