Abstract
To evaluate the influence of sepsis in the process of wound healing in the abdominal wall. 40 rats divided into two groups of twenty animals: group of study (E) - septic, and the control group (C) - not septic. The two groups were divided into subgroups of 10 to be killed on the third day (n = 10) or seventh (n = 10) postoperative. Sepsis was induced by ligation and puncture of the cecum. We performed also the section and anastomosis in left colon. The synthesis of the abdominal wall was made with 3-0 silk thread. On the day of re-laparotomy, the abdominal wall was removed for analysis of the breaking strength and histopathological analysis. The mean breaking strength was at third day: E group (1.44 ± 1.22) and C group (0.35 ± 0.46). At seventh day the mean breaking strength was: E group (13.01 ± 7.09) and C group (11.66 ± 7.38). There was statistical difference in tensile strength. E group at third day with control group (p = 0.019). The induction of peritoneal sepsis reduced the breaking strength of the abdominal wall on the third day after surgery.
Highlights
MethodsWidespread infections are responsible for 10-50% of deaths in intensive care units - ICUs -1, due release and formation of reactive oxygen species (ROS), important in the development of septic shock[2,3].Healing is a complex process divided into phases that follow chronologically and are interposed: homeostasis, proliferative phase, contraction and remodeling
The macrophages are truly essential to the healing process, since it “orchestrate” the release of cytokines that stimulates the subsequent healing process[4,7,8,9]
There was no significant difference between groups in weight before and after surgery
Summary
MethodsWidespread infections are responsible for 10-50% of deaths in intensive care units - ICUs -1, due release and formation of reactive oxygen species (ROS), important in the development of septic shock[2,3].Healing is a complex process divided into phases that follow chronologically and are interposed: homeostasis, proliferative phase, contraction and remodeling. The mean tensile strength necessary to overcome the resistance of surgical wounds in abdominal walls were: the third day study group (1.40 ± 1.22), the seventh day study group (13.01 ± 7.09); third day control group (0.34 ± 0.46), the seventh day control group (11.66 ± 7.38) (Table 2).
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