Abstract
After rats had been treated with drugs for 36 hr, striatal and adrenal tyrosine hydroxylase (TH) activities were determined by the coupled decarboxylase method. Treatment with methamphetamine 10 mg/kg, s.c., depressed striatal TH activity but elevated adrenal enzyme activity. Neither chlopromazine nor haloperidol affected TH activity in the striatum; however, when either of these neuroleptic drugs was administered concurrently with methamphetamine, the depression of striatal enzyme activity produced by methamphetamine was prevented. Adrenal enzyme activity was increased by chlorpromazine 15 mg/kg, i.p.; when this dose was administered concurrently with methamphetamine, the enzyme activity was greater than that produced by either drug alone. In contrast to chlorpromazine, haloperidol 5 mg/kg, i.p., had no effect on adrenal TH activity and seemed to impair the elevation produced by methamphetamine.
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