Influence of medical BPS treatment on sexual function

Abstract

Benign prostate syndrome is frequently associated with sexual dysfunction. The therapeutic options discussed in the S2e guideline may be able to improve existing sexual dysfunctions but can also worsen disorders or even trigger new ones. What are the effects of therapeutic options as described in the S2e guideline on sexual function? By selective literature search related to benign prostate syndrome and sexual dysfunction adverse effects of drugsmentioned in the S2e guideline have been evaluated. Serenoa repens extracts do not have adverse effects on sexual function; this is also true for muscarine receptor antagonists. 5α-Reductase inhibitors frequently worsen erectile function, libido and ejaculation; selective α1-blockers have an adverse effect on ejaculation. Phosphodiesterase (PDE)-5inhibitors can improve sexual function. Acombination of α1-blockers and 5α-reductase inhibitors worsens sexual functions significantly. Asuitable therapy for benign prostate syndrome should be chosen jointly by the patient and the treating physician and should be adapted to personal needs. Effects on sexual functions have to be taken into consideration when choosing atherapy.