Abstract
Empty or nifedipine-loaded biodegradable poly( dl-lactide-co-glycolide) microspheres were prepared by the solvent evaporation method. Spherical microparticles of different size distribution were thus obtained. The evolution of the mean diameter and the extent of size distribution as a function of different preparation parameters were studied. The mean particle diameter decreased when the stirring rate, the surface-active agent concentration and the internal phase volume were increased. Microspheres of 12, 18 and 83 μm, with different nifedipine payloads were obtained. The in vitro release of the drug was evaluated under sink and non-sink conditions: the 12 and 18 μm microspheres provide the same linear profile for approx. 400 h. Under non-sink conditions, the 83 μm microspheres exhibit an S-shape release pattern.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
