Influence of high energy milling on the kinetics of the polymorphic transition from the monoclinic form to the orthorhombic form of (±)5-methyl-5-(4’-methylphenyl)hydantoin

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5-methyl-5-(4’-methylphenyl) hydantoin is a chiral compound whose racemic mixture crystallizes as a conglomerate. This molecule has two polymorphs: an orthorhombic form (stable form) and a monoclinic form of monotropic character. These forms share extensive structural analogies (identical 2D periodic fragment) and consistently their lattice energies are quite close. The analyses of the crystal structures lead to propose an irreversible polymorphic transition based on a destructive/reconstructive mechanism.