Abstract
The influence of three independent fluidized bed granulation process variables (inlet air temperature, atomizing air pressure and binder solution amount) on the flow rate of granules and on the tablet properties was studied using the 3 3 factorial design. The dependence of the flow rate of granules, the tablet friability and the disintegration time of tablets on the fluidized bed granulation process variables was explained using the multilinear stepwise regression analysis. The flow time of the granules was affected by all three factors. The friability and the disintegration time of tablets were affected by the binder solution amount and the atomizing air pressure. The influence of inlet air temperature on the tablet responses was insignificant.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call