Abstract
Multiple aneurysms occur rarely and have not been well investigated. The purpose of this study is to verify whether high rupture risk of multiple aneurysms is due to the interaction between multiple aneurysms’ geometrical characteristics. The following geometrical characteristics were varied in an idealized sidewall-type model: aneurysm a1’s dome-neck length ( S), size ratio, inflow angle ( α), distance between two aneurysms ( D), and the parent vessel’s angle ( θ). We varied the parent blood vessel and aneurysm sac a1’s geometrical characteristics to analyze their hemodynamic influence on aneurysm a2. By comparing the influence on aneurysm a2, we found that parent blood vessel geometrical characteristics such as the distance between aneurysms ( D) and the parent vessel’s angle ( θ) were the most hemodynamically influential characteristics examined. The impact of varying the aneurysm’s geometrical characteristics such as dome-neck length ( S), size ratio, and inflow angle ( α) was not obvious. The reason for the higher rupture rate of multiple aneurysms is not due to interactions between the aneurysm sacs but due to factors of each individual aneurysm.
Highlights
The cerebral aneurysm is a very serious disease and captures more and more attention of researchers
Our study aims to identify the hemodynamic influence between aneurysm sacs by varying the geometrical characteristics of one and studying its influence on another
As Lauric et al.[22] argued that the hemodynamic factors of bifurcation-type aneurysms are not influenced by changing geometric characteristics such as the size ratio (SR), we focused on sidewall aneurysms in this research
Summary
The cerebral aneurysm is a very serious disease and captures more and more attention of researchers. The rupture of cerebral aneurysm may lead to aneurysmal subarachnoid hemorrhage (SAH) and, severe disability or death. It has been found that approximately 5% of the population has such lesions,[1] and 20%–34% of these persons have multiple intracranial aneurysms.[2] Patients harboring multiple intracranial aneurysms are at a higher risk of rupture and a poor outcome than those with a single aneurysm. Many researchers believe that complex treatment management and complications from hemorrhage contribute to a poor outcome, but the exact justification for the high rupture rate of the multiple aneurysms remains unclear.[3,4]. The reasons for aneurysm initiation, growth, and rupture are complicated and are still not well understood.
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