Abstract
IDDM in Singaporean Chinese was associated with HLA B58, DRB1 ∗0301, DQB1 ∗0201, and joint occurrences of DRB1 ∗030 1/ ∗0901 and DRB1 ∗0301/ ∗04. Of the DR4s the frequencies of DRB1 ∗0401, ∗0404, and ∗0405 were higher and ∗0406 was lower in patients compared to controls. DRB1 ∗0301/ ∗0901 was observed mainly in female patients and the frequency showed an inverse relationship with age at onset, whereas DRB1 ∗0301/ ∗04 was observed mainly in male patients and also showed an inverse relationship with age at onset. DRB1 ∗1202 showed an increasing frequency with age at onset. IDDM patients had a higher frequency of homozygous NAsp57 DQβ chains and a lower frequency of homozygous Asp57 DQβ chains compared to controls, especially in younger onset patients.
Published Version
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