Influence of fascicle strain and corticospinal excitability during eccentric contractions on force loss.

Abstract

What is the central question of this study? Do neural and/or mechanical factors determine the extent of muscle damage induced by eccentric contractions? What is the main finding and its importance? The extent of muscle damage induced by eccentric contractions is related to both mechanical strain and corticospinal excitability measured at long muscle lengths during eccentric contractions. In this study, we investigated whether the mechanical and neural characteristics of maximal voluntary eccentric contractions would determine the extent of change in postexercise maximal voluntary isometric contraction (MVC) torque and muscle soreness. Eleven men performed 10 sets of 15 isokinetic (45degs-1 ) maximal voluntary eccentric knee extensions. Knee-extension torque and vastus lateralis fascicle length were assessed at sets 1, 5 and 9. Vastus lateralis motor evoked potential, maximal Mwave (MEP/M) and the cortical silent period (CSP) were measured at 75 and 100deg of knee flexion (0deg=full extension) during contractions and were normalized to MEP/M (MEP/Mecc/iso ) and CSP (CSPecc/iso ) recorded during isometric MVC at each angle. The MVC torque and muscle soreness of the knee extensors were assessed before, 24, 48 and 96 h after the eccentric contractions. The extent of relative decrease in MVC torque at 24h postexercise (r2 =0.38) and peak muscle soreness (r2 =0.69) were correlated (P<0.05) with MEP/Mecc/iso measured at 100deg, but not at 75deg. The average torque on the descending limb of the torque-angle relationship (r2 =0.16), fascicle elongation (r2 =0.18) and CSPecc/iso at both 75 (r2 =0.00) and 100deg (r2 =0.02) were not significantly correlated with the relative decrease in MVC torque. The relative decrease in MVC torque was best predicted by a combination of mean torque on the descending limb, fascicle elongation and MEP/Mecc/iso (R2 =0.93). It is concluded that the extent of muscle damage based on the reduction in MVC torque is determined by mechanical strain and corticospinal excitability at long muscle lengths during maximal voluntary eccentric contractions.