Abstract

Background: Transfusion of plateletpheresis is effective for treating patients with platelet relatedinsufficiencies while limiting recipient’sexposure to platelets from multiple donors. A larger yield isobtained when donor has a greater number of initial platelets and separation done in a shorter time. Theaim of the study was to analyze the effect of various donors and procedure related parameters on the yieldof single donor platelet so that blood donors can be screened effectively in less time.Materials and Methods: One thousand and one hundred plateletpheresis procedures were performed ina tertiary-care super-specialty hospital onFenwal AMICUS machine using closed system kits. Statisticalanalysis was done to establish cause and effect relationship and to find the extent of relationship betweendifferent variables.Results: Height, weight,BMI, platelet count and total leucocyte count had significant correlation withplatelet yield, processing time and blood volume processed while haemoglobin especially in femalescorrelated significantlywith processing time(p<0.0001)and blood volume processed. Rh “negative”donors had shorter processing time than Rh “positive” donors while ABO group did not show anycorrelation with machine variables.Conclusion: Platelet yield correlated positively with pre-donation count, height, weight and BMI.Haemoglobin correlated with processing time and blood volume processed. Optimization of platelet yieldis an emerging issue to identify factors which may help in selecting donors to obtain higher platelet yieldsin shorter time and consequently better clinical outcome.DOI: http://dx.doi.org/10.3126/jpn.v4i7.10292 Journal of Pathology of Nepal (2014) Vol. 4, 525-529

Highlights

  • IntroductionCorrespondence: Donor demographics and platelet yield limiting the recipient’s exposure to platelets from multiple donors

  • Plateletpheresis is the routine collection of platelets using an automated blood cell separator device, which results in the product Plateletpheresis manufactured from a highCorrespondence: Donor demographics and platelet yield limiting the recipient’s exposure to platelets from multiple donors

  • A total of 1100 healthy donors met the requirements for plateletpheresis on Amicus Cell Separator of Fenwal, USA with mean body weight of 77.32 ± 23.53 kg and mean Body Mass index (BMI)

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Summary

Introduction

Correspondence: Donor demographics and platelet yield limiting the recipient’s exposure to platelets from multiple donors. Administration of these platelets significantly reduced the risk of allo-immunization. There has been a trend towards the use of single donor platelet (SDP) rather than pooled random donor platelet (RDP) in patient with thrombocytopenia over the last decade.[1] This trend has been resulted from the observations that SDP is a better platelet product due to less number of donor exposures and consequent reduction in transfusion transmitted diseases, transfusion reactions and possibly allo-immunization.[2,3,4] Currently, more than 50% of platelets are produced by plateletpheresis in developed countries.[1] In India, because of economic constraints & limited resources, SDP is not in that much demand till date.[5]. The aim of the study was to analyze the effect of various donors and procedure related parameters on the yield of single donor platelet so that blood donors can be screened effectively in less time

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