Abstract
DNA samples from 318 children and adolescents (174 males, 144 females), exposed to radon at home and 65 children (23 males, 42 females) in the control group have been studied. Using the micronucleus test on buccal epithelial cells we identified a significant increase in the number of cells with cytogenetic and proliferative abnormalities in the exposed group. Associations between NBS1 (rs1805794), ATM (rs1801516), and ADPRT (rs1136410) genes polymorphisms and karyological abnormalities in buccal epithelial cells were investigated. For the exposed group, an association of NBS1 Glu185Gln polymorphism with an increased frequency of “broken egg”-type protrusions and apoptotic bodies was established. The NBS1 185Glu/Gln and the ATM1 1853Asp/Asp genotypes were associated with elevated levels of cytogenetic damage, while the NBS1 185Glu/Glu and ATM 1853Asp/Asn genotypes demonstrated a protective role. No significant associations were found in the control group.
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