Abstract
Influence of distinct radiotherapy techniques to induce second cancer risks in left breast cancer. Material and methods: Ten female patients with intact left breast cancer. Two treatment plans for each patient: 1) two tangential beams 3D-Conformal radiotherapy, 2) intensity-modulated radiotherapy (IMRT) plan. Estimation of second cancer risk from Organ equivalent dose models (OEDs) in three dose-response model for organs at risk in left breast cases. Results: The P-value for OED models in 3D-IMRT for left lung, both lung, heart, right lung, right breast, thyroid, liver and spinal cord in linear dose model was 0.016, 0.005, 0.019, 3.95E-06, 5.79E-07, 0.003, 1.78E-10 and 0.000206475 respectively, for linear exponential dose model 0.0577, 0.024, 0.031, 3.40E-06, 3.28E-07, 0.003, 2.01E-10 and 0.000120072 respectively and in plateau dose model 0.088, 0.042, 0.039, 3.18E-06, 2.53E-07, 0.003, 2.27E-10 and 9.00535E-05 respectively. Conclusion: organ equivalent dose models for organs at risk increasing in IMRT than tangential beams.
Highlights
The most common cancer in US women patients is breast cancer, which is the second reason for death in cancer patients
Conclusion: organ equivalent dose models for organs at risk increasing in IMRT than tangential beams
2) Tangential beams Three-dimensional conformal radiation therapy planning created with two tangent fields with energy 6 MV or 6 MV and 10 MV depending on the patient separation
Summary
The most common cancer in US women patients is breast cancer, which is the second reason for death in cancer patients. From preceding records regarding second radiation-induced cancer it confirmed occurrence over sarcoma of last irradiated area [5] [6] [7] [8] [9]. The modern studies reported dose-impact relationship for second radiation-induced cancers. They estimated that second cancer risk rises with increase dose [10]. The dose-response relationship is based on Radiobiological modeling to calculate harm of inducing cancer after radiotherapy. The best way to minimize the risk of second tumors is to decrease radiation dose to sites where the dose is already low [11] [12]. Literature showed that inversed planning (IMRT) results in better dose distribution than conformal radiotherapy (3D-CRT) for treatment of breast after conservative breast surgery [14]
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