Abstract
The objective of this study was the evaluation of different types of lactose on the powders flow properties and dissolution of tablets of formulations with captopril and amoxicillin. Data of powders flow rate, compressibility index and dissolution profiles of tablets are presented. The powders flow rate showed higher sensitivity to small changes in their properties, compared to compressibility index. SuperTabs 21AN and 24AN flow at least 20 times faster than Lactopress and lactose NF. Lubrication increases the flow rate, maintaining the observed comparative differences. Dilution of lactoses with 50% captopril or amoxicillin reduces drastically the powder flow, producing also an equalizing effect. The greater flowability of SuperTabs, compared to other types of lactose, practically disappears. Dissolution of lubricated and unlubricated lactose tablets show a much faster dissolution of SuperTab 21AN tablets followed by Lactopress, lactose NF and SuperTab 24AN tablets. Dilution of lactoses with 50% captopril displays a quite smaller dissolution rate with a comparative similar behavior as observed before while dilution with amoxicillin show an equalizing effect of drug dissolution with minor differences between lactoses. The effect of lactose excipients on dissolution is attributed in a greater extent to mechanical properties of their tablets than to differences in solubility and dissolution.
Highlights
Direct compression is an economical and flexible technology that relates to the growth in the pharmaceutical market of the excipients and equipment designed according to the state of the art of science and technology
Among SuperTabs, SuperTab 21 AN shows an about 50% greater flowability than SuperTab 24AN.The results indicate that both SuperTabs have significant higher flowability than the other chemical identical lactose powders
The flowability of the lubricated excipients and their mixtures was assessed using the compressibility index and the powder flow through a funnel with a given orifice size
Summary
Direct compression is an economical and flexible technology that relates to the growth in the pharmaceutical market of the excipients and equipment designed according to the state of the art of science and technology. The most important characteristics required in materials used in direct compression are compactibility and flowability. The judicious selection of excipients can improve the tableting properties of mixtures used in direct compression (Emshanova, 2008). The degree of consolidation is characteristic for each powder and the ratio of the bulk and tapped densities is correlated with the interparticle friction. A dynamic method can be as simple as measuring the rate at which the powder is discharged from a hopper. A valve is open for the complete discharge of the powder from the hopper, recording the time to calculate the flow rate of the powder mass
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