Abstract
Gastrointestinal absorption of lead was investigated in mice after oral administration of lead acetate labeled with 210Pb. When doses of 0.2, 2 and 20 mg of Pb/kg were given, the magnitude of the dose did not appear to affect significantly the percent absorbed. The presence of food in the gastrointestinal tract reduced lead absorption when a tracer dose was administered but did not affect absorption after 2 mg of Pb/kg po. The chelators nitrilotriacetic acid and sodium citrate increased absorption of lead, as did orange juice, a source of citric acid. Milk and the chelating agents, ethylenediaminetetraacetic acid and diethylenetriaminepentaacetic acid, did not affect significantly lead absorption.
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