Abstract
The effect of chelating agents given orally and parenterally in therapeutic doses (0.2 mmol/kg) on the gastrointestinal absorption of lead (50 mg/kg and 0.5 mg/kg) was investigated in female, 5- to 7-week-old rats using a method of radioactive 203Pb labeling. Intraperitoneal administration of calcium disodium ethylenediaminetetraacetate and 2,3-dimercaptopropanol increased significantly the intestinal lead absorption. Sodium citrate, d-penicillamine, calcium disodium ethylenediaminetetraacetate, and 2,3-dimercaptopropanol given orally caused an increase in the lead absorption from the bowel. The amount of lead retained in the body in this experiment was also increased by all chelating agents except calcium disodium ethylenediaminetetraacetate.
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