Abstract
Decortication, which causes degeneration of the cortico-striatal glutamateric afferents, markedly attentuates the neurotoxic action of kainic acid in the striatum. Injection of 1 μmol of L-glutamate alone in the decorticate striatum does not cause neuronal degeneration whereas the injection of 10 nmol of kainate with 1 μmol of L-glutamate partially restores kainate's neurotoxicity. The results suggest that kainate's neurotoxicity is affected by the synaptic input to vulnerable neurons and may involve a cooperative interaction with synaptically released L-glutamate.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
